Start your day with a guided tour that delves into the history and culture of one of Baltimore’s distinct neighborhoods. On a small-group tour of the Mount Vernon area, for example, you might see the country’s first monument to George Washington, filming locations of popular TV shows, the Baltimore Basilica, and America’s first Catholic church. Some tours include snack breaks.

After working up an appetite in the morning, embark on a food-focused afternoon tour of another neighborhood. A guided tour through the cobblestone streets and past the row houses in Fell’s Point takes you to family-run restaurants to sample Polish cuisine, Baltimore-style pit beef, and Spanish tapas. Another foodie favorite is a tour through Little Italy and Jonestown to sample the specialties of early-19th-century Jewish and Italian immigrants, from fresh knishes to homemade meatballs. If there’s time afterward, go on a tour of the Sagamore Spirit Distillery and taste some American straight rye whiskey.

Soak up the waterfront sights on an evening cruise around Baltimore’s Inner Harbor. You’ll find multiple cruise options, from a luxe dinner yacht experience to a more casual sunset sail aboard a schooner. Most tours pass popular attractions such as the Maryland Science Center and the Francis Scott Key Bridge. After you dock, you’ll be in the perfect place to take in the Inner Harbor nightlife scene and toast your day in Charm City.